Howard M. Johnson, Ph.D.
Graduate Research Professor
Microbiology and Cell Science, IFAS
2002 AwardeeHoward Johnson believes humans may someday be vaccinated against some forms of cancer in the same way they are now protected from diseases likes polio and influenza.
“Vaccination against infectious diseases is not a miraculous event,” Johnson says. “What you basically do is inject a part of the harmful organism into an individual under circumstances that will not allow it to grow or cause disease. This stimulates the immune system so it is able to kill the infectious agent before it can get a foothold. Theoretically, one could use a similar approach dealing with cancers.”
Johnson is already developing such an approach. He has successfully immunized laboratory mice against melanoma, one of the most aggressive forms of skin cancer. Some immunized mice have survived for as long as 150 days after exposure to active melanoma cells, while unprotected mice died in a matter of weeks.
Johnson’s research focuses on superantigens and the role they play in activating cell responses. Superantigens are proteins that are strong stimulators of the immune system. Johnson uses superantigens to boost the response to a vaccine, in this case an injection of dead melanoma cancer cells. He believes superantigens may eventually result in preventive treatments for cancer and other diseases.